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《医学前沿(英文)》 2013年 第7卷 第3期 页码 280-289 doi: 10.1007/s11684-013-0265-3
Many gene fusions have been recognized as important diagnostic and/or prognostic markers in human malignancies. In recent years, novel gene fusions have been identified in cases without prior knowledge of the genetic background. Accompanied by a powerful computational data analysis method, new genome-wide screening approaches were used to detect cryptic genomic aberrations. This review focused on advanced genome-wide screening approaches in fusion gene identification, such as microarray-based approaches, next-generation sequencing, and NanoString nCounter gene expression system. The fundamental rationale and strategy for fusion gene identification using each biotech platform are also discussed.
关键词: gene fusion cancer microarray next-generation sequencing NanoString nCounter system
Magnetic confinement fusion: a brief review
Chuanjun HUANG, Laifeng LI
《能源前沿(英文)》 2018年 第12卷 第2期 页码 305-313 doi: 10.1007/s11708-018-0539-1
关键词: fusion energy magnetic confinement tokamak structural material superconducting magnet
Turbidity-adaptive underwater image enhancement method using image fusion
《机械工程前沿(英文)》 2022年 第17卷 第3期 doi: 10.1007/s11465-021-0669-8
关键词: turbidity underwater image enhancement image fusion underwater robots visibility
M-LFM: a multi-level fusion modeling method for shape−performance integrated digital twin of complex
《机械工程前沿(英文)》 2022年 第17卷 第4期 doi: 10.1007/s11465-022-0708-0
关键词: shape−performance integrated digital twin (SPI-DT) multi-level fusion modeling (M-LFM) surrogate model telescopic boom crane data fusion
Gradient-based compressive image fusion
Yang CHEN,Zheng QIN
《信息与电子工程前沿(英文)》 2015年 第16卷 第3期 页码 227-237 doi: 10.1631/FITEE.1400217
关键词: Compressive sensing (CS) Image fusion Gradient-based image fusion CS-based image fusion
Information fusion in aquaculture: a state-of the art review
Shahbaz Gul HASSAN,Murtaza HASAN,Daoliang LI
《农业科学与工程前沿(英文)》 2016年 第3卷 第3期 页码 206-221 doi: 10.15302/J-FASE-2016111
关键词: aquaculture computer vision information fusion modeling sensor
Iterative HOEO fusion strategy: a promising tool for enhancing bearing fault feature
《机械工程前沿(英文)》 2023年 第18卷 第1期 doi: 10.1007/s11465-022-0725-z
关键词: higher order energy operator fault diagnosis manifold learning rolling element bearing information fusion
《机械工程前沿(英文)》 2023年 第18卷 第3期 doi: 10.1007/s11465-023-0760-4
关键词: multi-information fusion contact detection quadruped robot probabilistic contact model unstructured terrain
Christopher John NASSAU, N. Scott LITOFSKY, Yuyi LIN
《机械工程前沿(英文)》 2012年 第7卷 第3期 页码 247-255 doi: 10.1007/s11465-012-0335-2
Subsidence, when implant penetration induces failure of the vertebral body, occurs commonly after spinal reconstruction. Anterior lumbar interbody fusion (ALIF) cages may subside into the vertebral body and lead to kyphotic deformity. No previous studies have utilized an artificial neural network (ANN) for the design of a spinal interbody fusion cage. In this study, the neural network was applied after initiation from a Taguchi L18 orthogonal design array. Three-dimensional finite element analysis (FEA) was performed to address the resistance to subsidence based on the design changes of the material and cage contact region, including design of the ridges and size of the graft area. The calculated subsidence is derived from the ANN objective function which is defined as the resulting maximum von Mises stress (VMS) on the surface of a simulated bone body after axial compressive loading. The ANN was found to have minimized the bone surface VMS, thereby optimizing the ALIF cage given the design space. Therefore, the Taguchi-FEA-ANN approach can serve as an effective procedure for designing a spinal fusion cage and improving the biomechanical properties.
关键词: anterior lumbar interbody fusion (ALIF) artificial neural network (ANN) finite element interbody cage lumbar interbody fusion subsidence taguchi method
夏家辉
《中国工程科学》 2000年 第2卷 第11期 页码 1-11
介绍了中国医学遗传学国家重点实验室在遗传病家系收集、疾病基因定位、疾病基因克隆和疾病基因功能研究方面的研究工作。用细胞遗传学G显带技术于1975年发现了一条与鼻咽癌相关的标记染色体t(1;3)(q44;p11);1981年将睾丸决定基因(TDF)定位于Yp11.32带;1991年以来收集遗传病家系345种共590个;1996年用显微切割、PCR、微克隆技术克隆了EXT2基因;1998年用基因家族-候选疾病基因克隆方法克隆了遗传性神经性耳聋基因GJB3;1999年用连锁分析和全基因组扫描将一种遗传性弥漫性浅表性光敏性汗孔角化症定位于12q23.2带,并在基因功能研究中发现了一个新的细胞内转运蛋白。
关键词: 遗传病家系 基因定位和克隆 基因家族-候选疾病基因克隆 基因组扫描 基因功能研究
Development and testing of a wireless smart toolholder with multi-sensor fusion
《机械工程前沿(英文)》 2023年 第18卷 第4期 doi: 10.1007/s11465-023-0774-y
关键词: wireless smart toolholder multi-sensor fusion circular runout dynamic balancing static stiffness dynamic inherent frequency
Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing
Yu Cao, Xiaoxuan Liu, Ling Peng
《化学科学与工程前沿(英文)》 2017年 第11卷 第4期 页码 663-675 doi: 10.1007/s11705-017-1623-5
关键词: gene therapy RNAi therapeutics dendrimer nanovectors gene silencing
陈双叶,张微敬
《中国工程科学》 2006年 第8卷 第12期 页码 75-79
将粗糙集理论和模糊逻辑技术结合起来,提出了一种基于粗糙集数据处理的模糊信息融合方法。运用粗糙集的基本理论和简约计算方法,从大量原始数据中发现精简的、概略化的规则,结合模糊逻辑推理建立一致粗糙模糊模型,并提出了对模型进行扩充与完备化的概念。脉动真空灭菌温度控制过程的仿真试验研究结果表明了所提方法的有效性和可行性。
The antibiotic resistome: gene flow in environments, animals and human beings
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《医学前沿(英文)》 2017年 第11卷 第2期 页码 161-168 doi: 10.1007/s11684-017-0531-x
The antibiotic resistance is natural in bacteria and predates the human use of antibiotics. Numerous antibiotic resistance genes (ARGs) have been discovered to confer resistance to a wide range of antibiotics. The ARGs in natural environments are highly integrated and tightly regulated in specific bacterial metabolic networks. However, the antibiotic selection pressure conferred by the use of antibiotics in both human medicine and agriculture practice leads to a significant increase of antibiotic resistance and a steady accumulation of ARGs in bacteria. In this review, we summarized, with an emphasis on an ecological point of view, the important research progress regarding the collective ARGs (antibiotic resistome) in bacterial communities of natural environments, human and animals, i.e., in the one health settings. We propose that the resistance gene flow in nature is “from the natural environments” and “to the natural environments”; human and animals, as intermediate recipients and disseminators, contribute greatly to such a resistance gene “circulation.”
Advances in polishing of internal structures on parts made by laser-based powder bed fusion
《机械工程前沿(英文)》 2023年 第18卷 第1期 doi: 10.1007/s11465-022-0724-0
关键词: laser-based powder bed fusion polishing internal structures surface quality surface features post process additive manufacturing
标题 作者 时间 类型 操作
Identification of cancer gene fusions based on advanced analysis of the human genome or transcriptome
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期刊论文
M-LFM: a multi-level fusion modeling method for shape−performance integrated digital twin of complex
期刊论文
Information fusion in aquaculture: a state-of the art review
Shahbaz Gul HASSAN,Murtaza HASAN,Daoliang LI
期刊论文
Contact detection with multi-information fusion for quadruped robot locomotion under unstructured terrain
期刊论文
Analysis of spinal lumbar interbody fusion cage subsidence using Taguchi method, finite element analysis
Christopher John NASSAU, N. Scott LITOFSKY, Yuyi LIN
期刊论文
Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing
Yu Cao, Xiaoxuan Liu, Ling Peng
期刊论文